EBM, Biostatistics & Literature Review Course
Faculty:
- Anthony J. Busti, MD, PharmD, FNLA, FAHA
Topics Covered
Introduction to Clinical Research & Literature Interpretation
- Intro Lecture on Topics Covered & How to Use
Study Design, Development, & Interpretation
- Hypothesis Testing
- Study Design
- Type of Bias in Research
- Internal & External Validity
The Basics of Biostatistics - Part 1
- General Overview - What is the Endpoint?
- Measures of Central Tendency, Variability, & Dispersion
- Types of Study Groups: Related or Independent Groups
- Nominal, Ordinal, vs Continuous Data
- Parametric vs. Nonparametric Statistical Analysis
The Basics of Biostatistics - Part 2
- Power
- Alpha value
- Confidence Intervals
- P-values
- Relative Risk, Absolute Risk, & Odds Ratio
- Correlations & Coefficient of Variation
- Regression Analysis
Diagnostic Tests: Properties & Evaluation
- Precision and Accuracy
- Sensitivity & Specificity
- Receiver Operator Characteristic (ROC)
- Positive & Negative Predictive Values
- LIkelihood Ratios
Systematic Reviews & Meta-Analyses
- What is the Difference Between Them?
- Key Steps Involved
- Reporting the Results - The Forest Plot
- The GRADE Assessment
- Reporting Guidelines & Critical Appraisal
Clinical Literature, Evaluation & Critical Appraisals
- Reporting Guidelines of Studies
- Critical Appraisal Tools
- Assessment for Bias in Publications
Special Topics
- Pharmacoeconomic Analysis
- FDA New Drug Approval Process
- Medication Errors Reporting and Safety
- HIPPA Review
- Medication Therapy Management
- Disease State Management
